20 June 2024
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Non-human primates are becoming the go-to model for stem cell therapy research due to their close genetic and physiological parallels with humans. This new culture method allows for the in vitro cultivation and derivation of monkey pluripotent stem cells, free from animal-derived substances, paving the way for safer and more effective preclinical trials in biotech therapies.

Wow, what we’re looking at here is a pretty fascinating development in the world of science! Researchers have been working hard to figure out ways to study stem cells, which are like the Swiss Army knives of cells – they can turn into all sorts of other cells in the body. Now, these smart folks have come up with a new method to grow and study monkey stem cells in the lab without using any animal-derived products. That’s what “xeno-free” means – no foreign animal substances involved. It’s kind of like making a cake and making sure it’s completely free of nuts for someone with allergies.



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Now, why monkeys, you might ask? Well, monkeys are a lot like us in many ways, more so than, say, a mouse or a fruit fly. Because they’re so similar, they can tell us a lot about how certain treatments might work in humans. This is super important when scientists are trying to make sure new medicines or therapies are safe before they are used in people.

With this new system, scientists can actually keep an eye on the stem cells they put into monkey embryos. Imagine being able to track where your little brother or sister goes in a huge amusement park because they’re wearing a super bright neon shirt. These researchers are using a special kind of light-producing gene (like a biological neon shirt) to track the stem cells, so they can see where they’re going and what they’re doing inside the monkey’s body.

Why does this matter? Well, by understanding how stem cells work in monkeys, scientists can get a better idea of how to use them to treat diseases in humans. Maybe one day, we could fix damaged organs or even grow new ones. And by doing it in a way that doesn’t rely on animal products, we’re also being more ethical and sustainable.

Just think about it: we’re living in a time when we can watch cells in action inside another living being! It’s like having a magic magnifying glass that shows us the secrets of how life works. And who knows? This kind of research might one day lead to breakthroughs that could change medicine as we know it. Isn’t science amazing? Keep being curious, because every question you ask could lead to the next big discovery!

SOURCE: A chemically defined, xeno-free culture system for culturing and deriving monkey pluripotent stem cells in vitro

https://phys.org/news/2023-12-chemically-xeno-free-culture-culturing-deriving.html

FAQ’s

1. What does “xeno-free” mean in the context of growing and studying stem cells?

“Xeno-free” means that no animal-derived products are used in the process of growing and studying stem cells. It ensures that foreign animal substances are not involved in the research.

2. Why are monkeys used in stem cell research instead of other animals?

Monkeys are used in stem cell research because they are more similar to humans in many ways compared to other animals like mice or fruit flies. This similarity allows researchers to gain valuable insights into how certain treatments might work in humans.

3. How do researchers track the stem cells inside the monkey’s body?

Researchers use a special kind of light-producing gene to track the stem cells. This gene acts like a biological neon shirt, allowing scientists to see where the stem cells are going and what they are doing inside the monkey’s body.

4. Why is understanding how stem cells work in monkeys important for treating diseases in humans?

Understanding how stem cells work in monkeys helps scientists get a better idea of how to use them to treat diseases in humans. It provides valuable insights into potential treatments, such as repairing damaged organs or growing new ones.

5. How does studying stem cells in a way that doesn’t rely on animal products contribute to ethics and sustainability?

Studying stem cells in a way that doesn’t rely on animal products is more ethical and sustainable. It reduces the reliance on animal-derived substances, promoting a more ethical approach to scientific research and ensuring sustainability in the long run.



Related Wikipedia Articles

Topics: Stem cells, Primate (mammal), Pluripotent stem cell

Stem cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms,...
Read more: Stem cell

Primate
Primates is an order of mammals, which is further divided into the strepsirrhines, which include lemurs, galagos, and lorisids; and the haplorhines, which include tarsiers; and the simians, which include monkeys and apes. Primates arose 85–55 million years ago first from small terrestrial mammals, which adapted for life in tropical...
Read more: Primate

Cell potency
Cell potency is a cell's ability to differentiate into other cell types. The more cell types a cell can differentiate into, the greater its potency. Potency is also described as the gene activation potential within a cell, which like a continuum, begins with totipotency to designate a cell with the...
Read more: Cell potency

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